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|Fredric March||William Spence|
|Martha Scott||Hope Morris Spence|
|Beulah Bondi||Mrs. Lydia Sandow|
|Gene Lockhart||Preston Thurston|
|Elisabeth Fraser||Eileen Spence at Age 17|
|Harry Davenport||Elias Samson|
|Laura Hope Crews||Mrs. Preston Thurston|
|Grant Mitchell||Clayton Potter|
|Moroni Olsen||Dr. John Romer|
The film follows the life of a minister and his family and the various difficulties and people they encounter as they move from parish to parish. Minister Spence starts with a strict religious view of ministry but grows to appreciate the life of a younger generation and how he needs to minister to people, and not just going through rituals and customs.