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Following the death of her newborn baby, war widow LouLou Mason accepts a temporary two-week assignment as nursemaid to the infant son of corset manufacturer Frederick K. Begley, who lost his wife in childbirth. She ingratiates herself with the family and eventually becomes a permanent fixture. When she declines Frederick's proposal, he marries his secretary Alicia Torgersen, who fires LouLou following her honeymoon.
LouLou finds employment with wealthy Henry and Fleur Palfrey and begins to care for baby Robbie. Older son Harrison is expelled from boarding school due to poor grades and bad behavior and returns home with his tutor, Jerry Kean. When Jerry is offered a job in Beirut, he impulsively proposes to LouLou, who accepts. While waiting for his fiancée to pack, Jerry speaks to Fleur, who warns him about marrying a woman he barely knows. Having second thoughts, he suggests he and LouLou wait a few months before marrying, and she remains with the Palfreys.
Years pass, and LouLou is nursemaid to Stephanie, the twelve-year-old daughter of fading musical actress Annie Rawlins. When Annie is delayed at an audition and misses Stephanie's confirmation, the girl tells her friends LouLou is her mother. Realizing the girl has become too attached to her, Loulou decides to find work elsewhere.
Just prior to the start of World War II, LouLou accepts a job with Helen and Hugh Williams. Hugh joins the military and is injured in battle, prompting his wife to join him in England. Two years pass, and the widowed Helen, who still has not returned home, stops sending money to support her son Tony. LouLou accepts responsibility for the boy and raises him as her own. Years later, when Helen notifies her she is returning with her new husband, LouLou flees to Florida with Tony, but is arrested and charged with kidnapping. Although he is sympathetic to LouLou's situation, the district attorney is compelled by law to return Tony to Helen.
Now too old to be entrusted with the care of a baby, LouLou accepts a janitorial job in an elementary school in order to be close to children. When she visits an ophthalmologist, she discovers he is Robbie Palfrey, the now adult son of her former employees. Robbie invites her to his home for dinner the following week and arranges for all the children for whom she cared to be there with their spouses. As LouLou catches up with her former charges, Robbie announces he wants her to be the nanny for his own children.