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|George Brent||Professor Warren|
|Ethel Barrymore||Mrs. Warren|
|Kent Smith||Dr. Parry|
|Gordon Oliver||Steve Warren|
|Elsa Lanchester||Mrs. Oates|
|Sara Allgood||Nurse Barker|
|Rhys Williams||Mr. Oates|
|Dorothy McGuire||Helen Capel|
Set in early 20th century New England, the film is about a serial killer who murders disabled young women in the community. His next victim apparently is Helen (McGuire), a mute girl working as a live-in companion for the wealthy, bedridden Mrs. Warren (Barrymore).
Mrs. Warren urges her to leave the house, as does Dr. Parry, who knows the reason for Helen's loss of speech and hopes to help her get her voice back. Rounding out the household are Mrs. Warren's son and stepson, her verbally abused nurse, a secretary, a handyman and his wife, a housekeeper with a taste for brandy.